Effect of antacids on the dissolution behaviour of methacycline and doxycycline.
نویسندگان
چکیده
The effect of antacids on the dissolution behaviour of methacycline and doxycycline capsules from commercial dosage forms were studied. The dissolution of both tetracyclines was found to be markedly retarded by antacids such as magnesium trisilicate and magnesium oxide. An attempt was made to elucidate the mechanism of this effect. The results suggest that the effect of antacids on the dissolution may be due to the absorption of the drugs on antacids particles, as well as to the increased pH of the medium (JPMA 34: 59, 1984).
منابع مشابه
Resistance to various tetracyclines mediated by transposon Tn10 in Escherichia coli K-12.
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عنوان ژورنال:
- JPMA. The Journal of the Pakistan Medical Association
دوره 34 3 شماره
صفحات -
تاریخ انتشار 1984